| Primary Identifier | IPR037304 | Type | Domain |
| Short Name | TRAF3_MATH |
| description | Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling []. It is a critical regulator of both innate and adaptive immune responses []. TRAF3 plays a role in the regulation of B-cell survival [], in the regulation of antiviral responses [], and in T-cell dependent immune responses []. It is required for normal antibody isotype switching from IgM to IgG []. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [].TRAF3 contains a RING finger domain, five zinc finger domains, and a TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors []. |
