| Primary Identifier | IPR044420 | Type | Domain |
| Short Name | SMYD3_SET |
| description | This entry represents the SET domain of SET and MYND domain-containing protein 3 (SMYD3). SMYD3 functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4 []. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex []. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumours, and has been implicated as an oncogene in human malignancies []. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ]. |
