| Primary Identifier | IPR007528 | Type | Family |
| Short Name | RINT1_Tip20 |
| description | This entry includes RINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity []. They are part of the CATCHR (complexes associated with tethering containing helical rods) family which comprises the exocyst, COG, GARP, and DSL1 complexes and share a similar structure organisation with an N-terminal coiled-coil and a C-terminal α-helical bundle, which might be a protein-protein interaction module necessary for the formation of functional complexes.RINT-1 interacts with Rad50 only during late S and G2/M phases and participates in radiation induced checkpoint control []. RINT-1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [, , ].Tip20 is involved in the retrograde transport from the Golgi to the ER [, ].Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants [, ]. |
