| Primary Identifier | IPR045106 | Type | Family |
| Short Name | Kti12 |
| description | Budding yeast Protein Kti12 associates with Elongator complex, a six-subunit complex involved in tRNA modification [, ]. Kti12 is not a structural subunit but may play a regulatory role in Elongator function [, , , ]. It has been shown that Kti12 is associated with chromatin throughout the genome, even in non-transcribed regions and in the absence of Elongator []. It is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA [].In plants, proteins from this family have been related to tRNA wobble uridine modification, stress response and drought stress tolerance []. |
