| Primary Identifier | IPR037803 | Type | Domain |
| Short Name | PRG_PH |
| description | Rho guanine nucleotide exchange factor 11, also known as PDZ-RhoGEF, is a guanine nucleotide exchange factor (GEFs) for Rho GTPase that plays critical roles in signalling []. PDZ-RhoGEF uses its PDZ domains to bind class B plexins and plays a role in axon guidance [, ]. It is involved in neurotrophin-induced neurite outgrowth [].PDZ-RhoGEF contains an N-terminal PDZ domain, a regulators of G-protein signaling-like (RGSL) domain, a linker region, and C-terminal Dbl-homology (DH) and pleckstrin-homology (PH) domains which bind and catalyze the exchange of GDP for GTP on RhoA. This entry represents the PH domain []. |
