| First Author | Grailhe R | Year | 1999 |
| Journal | Neuron | Volume | 22 |
| Issue | 3 | Pages | 581-91 |
| PubMed ID | 10197537 | Mgi Jnum | J:54098 |
| Mgi Id | MGI:1334096 | Doi | 10.1016/s0896-6273(00)80712-6 |
| Citation | Grailhe R, et al. (1999) Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron 22(3):581-91 |
| abstractText | In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula. When exposed to novel environments, the 5A-KO mice displayed increased exploratory activity but no change in anxiety-related behaviors. In addition, the stimulatory effect of LSD on exploratory activity was attenuated in 5A-KO mice. These results suggest that 5-HT5A receptors modulate the activity of neural circuits involved specifically in exploratory behavior and suggest that some of the psychotropic effects of LSD may be mediated by 5-HT5A receptors. |
