| First Author | Liu JP | Year | 2000 |
| Journal | Mol Cell Biol Res Commun | Volume | 3 |
| Issue | 3 | Pages | 129-35 |
| PubMed ID | 10860859 | Mgi Jnum | J:63077 |
| Mgi Id | MGI:1860399 | Doi | 10.1006/mcbr.2000.0203 |
| Citation | Liu JP (2000) Telomerase: not just black and white, but shades of gray. Mol Cell Biol Res Commun 3(3):129-35 |
| abstractText | Telomerase, the telomeric DNA reverse transcriptase, plays a key role in the maintenance of telomeres in mammals and is required for immortalization of primary cells. Inexplicably, telomerase activation is sometimes associated with telomere shortening and inhibition leads not only to apoptosis but also increased tumorigenicity in rapidly renewing tissues of mouse and man. This article reviews the current evidence, both in vitro and in vivo, for telomerase function and the potential mechanisms, downstream of telomerase, in telomere signaling involving both the tumor-suppressor p53-dependent and independent pathways. Copyright 2000 Academic Press. |
