| First Author | Tufarelli C | Year | 2001 |
| Journal | Genomics | Volume | 71 |
| Issue | 3 | Pages | 307-14 |
| PubMed ID | 11170747 | Mgi Jnum | J:67727 |
| Mgi Id | MGI:1931338 | Doi | 10.1006/geno.2000.6394 |
| Citation | Tufarelli C, et al. (2001) Characterization of a Widely Expressed Gene (LUC7-LIKE; LUC7L) Defining the Centromeric Boundary of the Human alpha-Globin Domain. Genomics 71(3):307-14 |
| abstractText | We have identified the first gene lying on the centromeric side of the alpha-globin gene cluster on human 16p13.3. The gene, called 16pHQG;16 (HGMW-approved symbol LUC7L), is widely transcribed and lies in the opposite orientation with respect to the alpha-globin genes. This gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5' splice site selection. To examine the role of the 16pHQG;16 gene in delimiting the extent of the alpha-globin regulatory domain, we mapped its mouse orthologue, which we found to lie on mouse chromosome 17, separated from the mouse alpha-cluster on chromosome 11. Establishing the full extent of the human 16pHQG;16 gene has allowed us to define the centromeric limit of the region of conserved synteny around the human alpha-globin cluster to within an 8-kb segment of chromosome 16. Copyright 2001 Academic Press. |
