| First Author | Thapa P | Year | 2013 |
| Journal | Nat Commun | Volume | 4 |
| Pages | 1582 | PubMed ID | 23481390 |
| Mgi Jnum | J:205750 | Mgi Id | MGI:5546321 |
| Doi | 10.1038/ncomms2580 | Citation | Thapa P, et al. (2013) The transcriptional repressor NKAP is required for the development of iNKT cells. Nat Commun 4:1582 |
| abstractText | Invariant natural killer T cells have a distinct developmental pathway from conventional alphabeta T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T cell development is blocked at the double-positive stage. This cell-intrinsic block is not due to decreased survival or failure to rearrange the invariant Valpha14-Jalpha18 T cell receptor-alpha chain, but is rescued by overexpression of a rec-Valpha14-Jalpha18 transgene at the double-positive stage, thus defining a role for NKAP in selection into the invariant natural killer T cell lineage. Importantly, deletion of the NKAP-associated protein histone deacetylase 3 causes a similar block in the invariant natural killer T cell development, indicating that NKAP and histone deacetylase 3 functionally interact to control invariant natural killer T cell development. |
