| First Author | Tortorella MD | Year | 1999 |
| Journal | Science | Volume | 284 |
| Issue | 5420 | Pages | 1664-6 |
| PubMed ID | 10356395 | Mgi Jnum | J:55481 |
| Mgi Id | MGI:1338565 | Doi | 10.1126/science.284.5420.1664 |
| Citation | Tortorella MD, et al. (1999) Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [see comments]. Science 284(5420):1664-6 |
| abstractText | We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis. |
