| First Author | Pillutla RC | Year | 1999 |
| Journal | Genomics | Volume | 56 |
| Issue | 2 | Pages | 217-20 |
| PubMed ID | 10051408 | Mgi Jnum | J:53554 |
| Mgi Id | MGI:1332925 | Doi | 10.1006/geno.1998.5705 |
| Citation | Pillutla RC, et al. (1999) Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Genomics 56(2):217-20 |
| abstractText | Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion. We have obtained the complete sequence of TCEAL1, the gene that codes for p21/SIIR. This gene consists of three exons and two introns with the entire coding sequence in exon III. Tissue-specific expression patterns of TCEAL1 by Northern blot analysis showed the presence of an approximately 1.2-kb transcript in all normal human tissues examined, and heart and skeletal muscle contained an additional transcript of approximately 7 kb. Expression was lowest in hematopoietic cells of both normal and tumor origin. TCEAL1 was mapped to human chromosome Xq22.1 by fluorescence in situ hybridization. Copyright 1999 Academic Press. |
