| First Author | Okumura A | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 5 | Pages | 404-9 |
| PubMed ID | 23352894 | Mgi Jnum | J:201286 |
| Mgi Id | MGI:5512931 | Doi | 10.1016/j.febslet.2013.01.025 |
| Citation | Okumura A, et al. (2013) Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein. FEBS Lett 587(5):404-9 |
| abstractText | Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted hepatic protein that has been associated with several physiological activities. LECT2 belongs to the peptidase M23 family, suggesting that it is a zinc-binding protein. To test this possibility, electrospray ionization mass spectrometry and X-ray absorption fine-structure analysis were performed. Results of these experiments indicated that recombinant mouse LECT2 produced by an animal cell line contains a zinc atom. Furthermore, the recombinant LECT2 was found to be self-oligomerized by disulfide bonds in vitro, but this was suppressed by addition of zinc. These results indicated that zinc stabilizes the LECT2 structure. |
