| First Author | Lin LF | Year | 1993 |
| Journal | Science | Volume | 260 |
| Issue | 5111 | Pages | 1130-2 |
| PubMed ID | 8493557 | Mgi Jnum | J:38540 |
| Mgi Id | MGI:85922 | Doi | 10.1126/science.8493557 |
| Citation | Lin LF, et al. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science 260(5111):1130-2 |
| abstractText | A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. |
