| First Author | Reya T | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 1 | Pages | 15-24 |
| PubMed ID | 10933391 | Mgi Jnum | J:63678 |
| Mgi Id | MGI:1861366 | Doi | 10.1016/s1074-7613(00)00004-2 |
| Citation | Reya T, et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13(1):15-24 |
| abstractText | Lymphocyte enhancer factor-1 (LEF-1) is a member of the LEF-1/TCF family of transcription factors, which have been implicated in Wnt signaling and tumorigenesis. LEF-1 was originally identified in pre-B and T cells, but its function in B lymphocyte development remains unknown. Here we report that LEF-1-deficient mice exhibit defects in pro-B cell proliferation and survival in vitro and in vivo. We further show that Lef1-/- pro-B cells display elevated levels of fas and c-myc transcription, providing a potential mechanism for their increased sensitivity to apoptosis. Finally, we establish a link between Wnt signaling and normal B cell development by demonstrating that Wnt proteins are mitogenic for pro-B cells and that this effect is mediated by LEF-1. |
