| First Author | Occhiodoro T | Year | 1998 |
| Journal | FEBS Lett | Volume | 434 |
| Issue | 1-2 | Pages | 177-82 |
| PubMed ID | 9738473 | Mgi Jnum | J:49796 |
| Mgi Id | MGI:1278129 | Doi | 10.1016/s0014-5793(98)00973-9 |
| Citation | Occhiodoro T, et al. (1998) Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett 434(1-2):177-82 |
| abstractText | An early sign of human myoblast commitment to fusion is the expression of a non-inactivating delayed rectifier K+ current, I(K(NI)), and an associated membrane potential hyperpolarization. We have isolated the full-length coding region of a human ether-a-go-go K+ channel (h-eag) from myoblasts undergoing differentiation. The h-eag gene was localized to chromosome 1q32-41, and is expressed as a approximately 9 kb transcript in myogenic cells and in adult brain tissue. Forced expression of h-eag in undifferentiated myoblasts generates a current with remarkable similarity to I(K(NI)) indicating that h-eag constitutes the channel responsible for this current in vivo. |
