| First Author | Olayioye MA | Year | 2004 |
| Journal | Cancer Res | Volume | 64 |
| Issue | 10 | Pages | 3538-44 |
| PubMed ID | 15150109 | Mgi Jnum | J:90244 |
| Mgi Id | MGI:3042744 | Doi | 10.1158/0008-5472.CAN-03-3731 |
| Citation | Olayioye MA, et al. (2004) The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res 64(10):3538-44 |
| abstractText | We have identified that StarD10, a member of the START protein family, is overexpressed in both mouse and human breast tumors. StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. We have shown that StarD10 is capable of binding lipids. StarD10 was found to be overexpressed in 35% of primary breast carcinomas and 64% of human breast cancer cell lines, correlating with their ErbB2/Her2 status. Coexpression of StarD10 with ErbB1/epidermal growth factor receptor in murine fibroblasts enhanced anchorage-independent growth in soft agar, providing evidence for functional cooperation between StarD10 and ErbB receptor signaling. Taken together, these data suggest that overexpression of this lipid-binding protein contributes to breast oncogenesis. |
