| First Author | Itano A | Year | 1994 |
| Journal | Immunity | Volume | 1 |
| Issue | 4 | Pages | 287-90 |
| PubMed ID | 7889416 | Mgi Jnum | J:112749 |
| Mgi Id | MGI:3663458 | Doi | 10.1016/1074-7613(94)90080-9 |
| Citation | Itano A, et al. (1994) A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. Immunity 1(4):287-90 |
| abstractText | The CD8 coreceptor plays a critical role in the recognition of foreign antigens by mature T cells and in the development of class I-restricted T cells. CD8 can be expressed on the surface of T cells as either a heterodimer composed of an alpha and beta chain, or as a homodimer composed of two alpha chains. In this report, we show that a CD8 beta transgene that lacks a cytoplasmic domain can suppress expression of wild-type endogenous CD8 beta and act as a dominant negative mutation. We show that this dominant negative CD8 beta transgene interferes with the development of mature CD8 T cells to different extents depending on the individual class I-restricted TCR. These data suggest CD8 beta plays a role in thymic development, and that different class I-restricted TCRs differ in their dependence on the cytoplasmic tail of CD8 beta. |
