| First Author | Hobert O | Year | 2000 |
| Journal | Trends Genet | Volume | 16 |
| Issue | 2 | Pages | 75-83 |
| PubMed ID | 10652534 | Mgi Jnum | J:60218 |
| Mgi Id | MGI:1352983 | Doi | 10.1016/s0168-9525(99)01883-1 |
| Citation | Hobert O, et al. (2000) Functions of LIM-homeobox genes. Trends Genet 16(2):75-83 |
| abstractText | Homeobox genes play fundamental roles in development. They can be subdivided into several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of LIM-homeobox genes has been remarkably conserved through evolution. Have their functions similarly been conserved? A host of new data has been derived from mutational analysis in diverse organisms, such as nematodes, flies and vertebrates. These studies have revealed a prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date. Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements. |
