| First Author | Matthews JM | Year | 2013 |
| Journal | Nat Rev Cancer | Volume | 13 |
| Issue | 2 | Pages | 111-22 |
| PubMed ID | 23303138 | Mgi Jnum | J:193503 |
| Mgi Id | MGI:5468627 | Doi | 10.1038/nrc3418 |
| Citation | Matthews JM, et al. (2013) LIM-domain-only proteins in cancer. Nat Rev Cancer 13(2):111-22 |
| abstractText | LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma. These small proteins contain two protein-interacting LIM domains but little additional sequence, and they seem to function by nucleating the formation of new transcriptional complexes and/or by disrupting existing transcriptional complexes to modulate gene expression programmes. Through these activities, the LMO proteins have important cellular roles in processes that are relevant to cancer such as self-renewal, cell cycle regulation and metastasis. These functions highlight the therapeutic potential of targeting these proteins in cancer. |
