| Primary Identifier | IPR026648 | Type | Family |
| Short Name | ITPRID2 |
| description | SSFA2, also known as Ki-ras-induced actin-interacting protein (KRAP), interacts with inositol 1,4,5-trisphosphate receptor (IP3R, also known as ITPR) []. SSFA2 was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells []. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function []. |
