| Primary Identifier | IPR039122 | Type | Family |
| Short Name | TMEPAI |
| description | TMEPAI was originally identified as a highly androgen-induced gene by serial analysis of gene expression in androgen-treated LNCaP prostate cancer (CaP) cells []. It is a type I transmembrane protein that has an N-erminal extracellular and a single transmembrane domains. TMEPAI contains two PY motifs that can be targetedby the WW domain. It is involved in a negative feedback loop to control the duration and intensity of TGF-beta signaling, which regulates growth suppression, apoptosis induction, extracellular matrix production, and differentiation []. It is also involved in androgen receptor signalling, phosphatase and tensin homologue deleted on chromosome 10 signalling, and formation of autophagosomes in addition to degradation of TbetaRI (TGF-beta type I receptor) through lysosomes []. TMEPAI has been linked to cancers [, , ]. |
