| Primary Identifier | IPR043443 | Type | Family |
| Short Name | FYB1/2-like |
| description | This entry includes FYN-binding protein 1 and 2 (FYB1, FYB2) and PML-RARA-regulated adapter molecule 1 (PRAM1). Most of the proteins in this entry contain an altered SH3 domain fold.FYN-binding protein 1 (FYB1), also known as ADAP or SLAP, is an adapter protein in beta 1 integrin signalling and T lymphocyte migration []. It has been found to co-localise with F-actin in membrane ruffles, adhesion plaques/podosomes and phagocytic cups [, ]. In activated T cells, Fyb/SLAP associates with Ena/VASP family proteins and may link T cell signalling to the actin cytoskeleton remodelling []. FYB1 also interacts with mammalian actin binding protein 1 (mAbp1) that affects F-actin dynamics [].FYN-binding protein 2 (FYB2, also known as ARAP) is a adaptor protein required for TCR signaling and integrin-mediated adhesion [].PRAM1 is an intracellular adaptor molecule that is upregulated during the induced granulocytic differentiation of promyelocytic leukemic cells and during normal human myelopoiesis []. |
