| Primary Identifier | IPR043451 | Type | Family |
| Short Name | Myocardin-like |
| description | Myocardin (Myocd) is a coactivator of serum response factor (SRF), which is a key regulator of the expression of smooth and cardiac muscle genes. Myocardin plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) [, ]. It contains the RPEL repeats, which are monomeric globular actin (G-actin) binding elements. However, it binds to actin-related protein 5 (Arp5) instead of conventional actin, resulting in a significant suppression of Myocd activity [].Myocardin-related transcription factor A (MRTFA, also known MKL1) is an actin-binding transcriptional coactivator whose localisation is regulated by its interaction with monomeric actin (G-actin) []. Its N-terminal domain consists of three tandem RPEL repeats, where the G-actin binding site and the nuclear localisation signal can be found [, ]. In the nucleus MAL associates with SRF (serum response factor) and activates transcription of SRF:MAL-dependent target genes []. It has been implicated in human diseases, such as acute megakaryocytic leukemia []and other cancers [].MKL2 binds to and activates SRF (serum response factor) similar to myocardin and MKL1 [].This entry includes Myocardin and MKL/myocardin-like protein 1/2 (MKL1/2). |
