| Primary Identifier | IPR006581 | Type | Domain |
| Short Name | VPS10 |
| description | Yeast Vps10p is a receptor for sorting and transport of the soluble vacuolar hydrolase carboxypeptidase Y to the lysosome-like vacuole []. In mammalian cells, proteins containing this domain are involved in the transport of lipoproteins and sorting of endosomal proteins. They may also act as receptors for some neuropeptides.The N terminus of murine brain SorCS contains two putativecleavage sites for the convertase furin which mark the beginning of the VPS10domain, which is followed bya module of imperfect leucine-rich repeats and a transmembrane domain. Theshortintracellular C terminus contains consensus signals for rapidinternalization. The identifiedputative binding motifs for SH2 and SH3 domains are unique in the family ofVPS10 domainreceptors. SorCS is predominantly expressed in brain, but also in heart,liver, and kidney.SorCS transcripts detected by in situ hybridization in the murine centralnervous system pointto a neuronal expression [, ]. |
