| Primary Identifier | IPR006595 | Type | Domain |
| Short Name | CTLH_C |
| description | The 33-residue LIS1 homology (LisH) motif () is found in eukaryotic intracellularproteins involved in microtubule dynamics, cell migration, nucleokinesis andchromosome segregation. The LisH motif is likely to possess a conservedprotein-binding function and it has been proposed that LisH motifs contributeto the regulation of microtubule dynamics, either by mediating dimerization,or else by binding cytoplasmic dynein heavy chain or microtubules directly.The LisH motif is found associated to other domains, such as WD-40 (see), SPRY, Kelch, AAA ATPase, RasGEF, or HEAT (see )[, , ].The secondary structure of the LisH domain is predicted to be two alpha-helices [].Some proteins known to contain a LisH motif are listed below:Animal LIS1. It regulates cytoplasmic dynein function. In Homo sapiens (human) childrenwith defects in LIS1 suffer from Miller-Dieker lissencephaly, a brainmalformation that results in severe retardation, epilepsy and an earlydeath.Emericella nidulans (Aspergillus nidulans) nuclear migration protein nudF, the orthologue of LIS1.Eukaryotic RanBPM, a Ran binding protein involved in microtubulenucleation.Eukaryotic Nopp140, a nucleolar phosphoprotein.Mammalian treacle, a nucleolar protein. In human, defects in treacle arethe cause of Treacher Collins syndrome (TCS), an autosomal dominantdisorder of craniofacial development.Animal muskelin. It acts as a mediator of cell spreading and cytoskeletalresponses to the extracellular matrix component thrombospondin 1.Animal transducin beta-like 1 protein (TBL1).Plant tonneau.Arabidopsis thaliana LEUNIG, a putative transcriptional corepressor thatregulates AGAMOUS expression during flower development.Fungal aimless RasGEF.Leishmania major katanin-like protein.The C-terminal to LisH (CTLH) motif is a predicted α-helical sequence ofunknown function that is found adjacent to the LisH motif in a number of theseproteins but is absent in other (e.g. LIS1) [, , ]. The CTLH domain can alsobe found in the absence of the LisH motif, like in:Arabidopsis thaliana (Mouse-ear cress) hypothetical protein MUD21.5.Saccharomyces cerevisiae yeast protein RMD5. |
