| Primary Identifier | IPR043503 | Type | Homologous_superfamily |
| Short Name | PLpro_palm_finger_dom_CoV |
| description | In coronaviruses, papain-like protease (PL(pro)) cleaves the viral replicase polyproteins at different sites releasing non-structural protein NSP1, NSP2, NSP3, and a chymotrypsin-like protease (3CLpro) that cleaves all junctions downstream of NSP4 [].Structurally, coronaviruses papain-like protease consists of a C-terminal catalytic domain containing a right-handed fingers, palm, and thumb domain organisation as well as an N-terminal Ub-like (UBL) domain [, , ].This superfamily represents the palm and finger domains found in papain-like protease from beta and gamma coronaviruses, respectively consisting of 8 and 5 antiparallel β-sheets in MERS-CoV []and 6 and 4 antiparallel β-sheets in SARS-CoV []. |
