| Primary Identifier | IPR043369 | Type | Family |
| Short Name | MIA |
| description | Melanoma-derived growth regulatory protein or Melanoma inhibitory activity (MIA) is a 12kDa protein that is secreted from both chondrocytes and malignant melanoma cells. It has effects on cell growth and adhesion and it may play a role in melanoma metastasis and cartilage development. MIA elicits growth inhibition on melanoma cells in vitro. It is possible that secretion of MIA in vivo leads to decreased adhesiveness of melanocytic cells and thereby promotes melanoma progression and invasion []. Crystal structure revealed an Src homology 3 (SH)-like domain with N- and C-terminal extensions of about 20 aa each. It is thefirst structure of a secreted protein that contains an SH3 subdomain. MIA SH3 subdomain shares sequence similarity with canonical SH3 domains, suggesting that they are evolutionary related. It has a protein interaction site and, unlike conventional SH3 domains, MIA does not recognise polyproline helices []. |
