| Primary Identifier | IPR043384 | Type | Family |
| Short Name | RETREG1/3 |
| description | This entry include reticulophagy receptor 1 and reticulophagy receptor 3.Reticulophagy receptor 1, previously known as FAM134B, is essential for endoplasmic reticulum (ER) homeostasis. It is a ER resident receptor that binds to autophagy modifiers LC3 and GABARAP, and facilitates ER degradation by autophagy. It may promote membrane remodelling and ER scission via the membrane-bending capacity of its reticulon domain, whereas its LIR motif may be necessary to target the ER fragments to autophagosomes for lysosomal degradation [].Reticulophagy regulator 3 (RETREG3), also known as FAM134C, mediates NRF1-enhanced neurite outgrowth. NRF1 (nuclear respiratory factor-1) is a major transcription factor that can positively regulate FAM134C []. Members of the FAM134 protein family, including FAM134C, are ER-resident receptors that bind to autophagy modifiers LC3 and GABARAP, and facilitate ER degradation by autophagy []. |
