Primary Identifier | IPR043407 | Type | Family |
Short Name | Nkap_D1 |
description | NF-kappa-B-activating protein (Nkap) is a highly conserved protein which functions as a transcriptional repressor on Notch target genes. It is required for T cell development and acquisition of functional competency [, , ]. It also plays a role in RNA splicing and processing involved in transcriptional repression, maintenance and survival of adult haematopoietic stem cells.Nkap is divided into three domains, an N-terminal domain containing RS repeats, a highly basic middle domain and the C-terminal domain () [, ].This entry represents uncharacterised proteins that contain Nkap domain 1. |