Primary Identifier | IPR028052 | Type | Domain |
Short Name | CENP-C_N_dom |
description | CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C, proper formation of both centromeres and kinetochores is prevented. In kinetochores, the KMN (KNL1/Mis12/Ndc80) network regulates kinetochore microtubule binding []. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex to centromeres [, ]. |