| Primary Identifier | IPR033655 | Type | Domain |
| Short Name | TGS_RelA/SpoT |
| description | RelA/SpoT homologue (RSH) proteins play a central role in bacterial stringent response. RelA (also referred to as ppGpp hydrolase/synthetase) and SpoT are activated during stress conditions and synthesize transcriptional modulators (p)ppGpp that allow bacteria to adapt to this condicions. They contain a TGS domain, named after the Threonyl-tRNA Synthetase, GTPase, and SpoT proteins where it occurs []. This domain of RelA binds the CCA tail to orient the free 3' hydroxyl group of the terminal adenosine towards a β-strand, thus an aminoacylated tRNA at this position would be sterically impeded. This association suppresses auto-inhibition and activates the synthesis of (p)ppGpp and initiates the stringent response. [, ]. |
