| Primary Identifier | IPR043663 | Type | Family |
| Short Name | MODA-like |
| description | This entry represents a family of NAD-protein ADP-ribosyltransferases found in Myoviridae, including ModA from the bacteriophage T4 [].Bacteriophage T4 codes for three ADP-ribosyltransferases: Alt, ModA, and ModB. The ADP-ribosylating activity of each is directed to a specific set of host proteins. ModA is known to modify subunits of RNA-polymerase [].Protein ADP-ribosylation is an important posttranslational modification catalyzed by a group of enzymes known as ADP-ribosyltransferases (ADP-RTs) []. ADP-RTs transfer single or multiple ADP-ribose moieties from NAD to a specific amino acid residue within a target protein, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation) []. ADP-ribosylation changes the electrostatic potential of a target protein by introducing two phosphate groups and may affect protein-DNA as well as protein-protein interactions []. Protein ADP-ribosylation plays versatile roles in multiple biological processes. |
