| Primary Identifier | IPR004114 | Type | Domain |
| Short Name | THUMP_dom |
| description | The THUMP domain (named afterTHioUridine synthases, RNA Methylases and Pseudouridinesynthases) is a module of 100-110 amino acid residues which is involvedRNA metabolism. It is shared by enzymes involved in at least three unrelated types of RNA-modification, namely methylation, pseudouridylation and thiouridylation. The THUMP domain can occur in stand-alone form orin association with a variety of catalytic domains, likemethylase, pseudo U-synthase or rhodanese. THUMP is anancient domain that apparently evolved prior to the divergence of the primary divisions oflife. It was initially predicted to have RNA-binding capacity but it was shown later that it associates with the adjacent FLD domain () to display the RNA-binding ability, leading to the delivery of a variety of RNA modification enzymes to their targets. The domain adopts an α/β fold, with two helices packed against a β-sheet [, , , ].Some proteins known to contain a THUMP domain are listed below:Bacterial and archaeal thiI-like 4-thiouridine synthases (also known as tRNA sulfurtransferases or Thiamine biosynthesis protein ThiI).Bacterial, archaeal and eukaryotic RNA methyltransferases.Archaeal pseudouridine synthases (PSUSs).Several uncharacterised proteins. |
