| Primary Identifier | IPR028139 | Type | Family |
| Short Name | Humanin |
| description | Humanin (HN) and humanin-like proteins are found exclusively in humans. Humanin is a short anti-apoptotic peptide that inhibits the activation of Bax (Bcl-2-associated X protein), which is involved in apoptosis []. Humanin suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults []. Humanin also interacts with the insulin-like growth factor-binding protein-3 (IGFBP-3), which is essential in the regulation of cell survival []. This entry represents the humanin family, and also matches some uncharacterised non-human proteins, mainly from chimpanzee. |
