| Primary Identifier | IPR015332 | Type | Family |
| Short Name | CH2-like |
| description | This entry includes major allergen I polypeptide chain 2 (Fel d 1 chain 2) from cat and related proteins, such as SCGB2B from mice.Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans. The nomenclature system uses the first three letters of the genus, followed by the first letter of the species name, followed by a number (additional letters can be added to the name as required to discriminate between similar designations).Fel d 1 is allergen 1 from Felis silvestris catus (Cat), which is an important agent in human allergic reactions []. The protein is expressed in saliva and sebaceous glands. The complete primary structure of Fel d 1 has been determined []. The allergen is tetrameric glycoprotein consisting of two disulphide-linked heterodimers of chains 1 and 2, which have been shown to be encoded by different genes. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides.SCGB2B is an androgen-binding protein that plays a role in mate selection in mice []. |
