| Primary Identifier | IPR034949 | Type | Domain |
| Short Name | RGS_RGS8 |
| description | The RGS (Regulator of G-protein Signalling) domain is an essential part of the RGS8 protein.RGS8 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS8 is involved in G-protein-gated potassium channels regulation [, ]and is predominantly expressed in the brain []. In the hematopoietic system, it is selectively expressed in natural killer (NK) cells []. |
