| Primary Identifier | IPR043597 | Type | Domain |
| Short Name | TPH_dom |
| description | This entry represents the trichohyalin-plectin-homology domain. This domain can be found in mitostatin (also known as trichoplein keratin filament-binding protein, TCHP) and related proteins [, ]. Trichoplein keratin filament-binding protein (TCHP) may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It may regulate K8/K18 filament and desmosome organisation mainly at the apical or peripheral regions of simple epithelial cells []. In human, it acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation []. |
