| Primary Identifier | IPR006627 | Type | Repeat |
| Short Name | TDU_repeat |
| description | The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses aTEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. InDrosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain.The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wingoutgrowth when ectopically expressed. The human protein, TONDU, contains a short domain homologous to the domain of Vg required for interaction withSd. TONDU specifically interacts with a domain conserved in all the mammalian TEF factors []. |
