| Primary Identifier | IPR034946 | Type | Domain |
| Short Name | LARP7_La |
| description | LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation [].LARP7 belongs to a group of factors that share an N-terminal La-like domain followed by one or two RNA-recognition motifs (RRM) []. This entry represents the La-like domain. |
