| Primary Identifier | IPR004023 | Type | Family |
| Short Name | Mago_nashi |
| description | This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene []. The protein is an integral member of the exon junction complex (EJC). The EJC is a multiprotein complex that is deposited on spliced mRNAs after intron removal at a conserved position upstream of the exon-exon junction, and transported to the cytoplasm where it has been shown to influence translation, surveillance, and localization of the spliced mRNA. It consists of four core proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP and is supposed to be a binding platform for more peripherally and transiently associated factors along mRNA travel. Mago and Y14 form a stable heterodimer that stabilizes the complex by inhibiting eIF4AIII's ATPase activity. Mago-Y14 heterodimer has been shown to interact with the cytoplasmic protein PYM, an EJC disassembly factor, and specifically binds to the karyopherin nuclear receptor importin 13 [, , , , , , , , , , , , , , , , ].The human homologue has been shown to interact with an RNA binding protein, ribonucleoprotein rbm8 () []. An RNAi knockout of the Caenorhabditis elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination []but the protein is also found in hermaphrodites and other organisms without a sexual differentiation. |
