| Primary Identifier | IPR003932 | Type | Family |
| Short Name | EMP_1 |
| description | The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities []. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length, and shares a common predicted transmembrane (TM) topology of 4 TM domains, with intracellular N- and C-termini [].EMP-1, previously termed tumour-associated membrane protein (TMP), was originally isolated from a mouse brain tumour []. Human, rat and rabbit isoforms have also been identified. EMP-1 is expressed in a wide range of tissues, including heart, placenta, lung, skeletal muscle, kidney and small intestine []. A role for the protein in the control of cell growth has been suggested []. EMP-1 is expressed at high levels in proliferating cells, and at reduced levels in cells undergoing growth arrest []. In contrast, PMP22, which is co-expressed with EMP-1 in a range of tissues, displays an inverse pattern of regulation, with high levels of expression in cultured cells undergoing growth arrest []. It has therefore been proposed that these proteins may have reciprocal functions in the control of cell quiescence and proliferation. |
