| Primary Identifier | IPR041254 | Type | Domain |
| Short Name | PCSK9_C1 |
| description | This entry represents the first subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds []. |
