| Primary Identifier | IPR016290 | Type | Family |
| Short Name | S-AdoMet_hydrolase |
| description | This entry represents S-adenosyl-L-methionine (SAM) hydrolases (), which catalyse the hydrolysis of S-adenosyl-L-methionine, cleaving it to form L-homoserine and methylthioadenosine. This enzyme is produced by Bacteriophage T3, which infects Escherichia coli cells. SAM hydrolase can remove S-adenosylmethionine from the E. coli cell, thereby inhibiting a variety of SAM-related activities, such as dam and dcm methylase-directed DNA modifications and the synthesis of spermidine from putrescine []. Expression of SAM hydrolase in T3-transformed E. coli induces the met regulon by cleaving the SAM co-repressor to form 5'-methylthioadenosine, which is then cleaved to produce 5-methylthioribose []. |
