| Primary Identifier | IPR028265 | Type | Family |
| Short Name | TTDN1/SICKLE |
| description | This entry includes animal M-phase-specific PLK1-interacting protein (also known as TTDN1) and plant protein SICKLE. M-phase-specific PLK1-interacting protein (also known as TTD non-photosensitive 1 protein, TTDN1) co-localises with Plk1 at the centrosome in mitosis and the midbody during cytokinesis []. TTDN1 is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1 (PLK1) [, ]. It may play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis []. Mutations in the C7orf11 (TTDN1) gene has been linked to Trichothiodystrophy (TTD), a rare autosomal recessive disorder whose defining feature is brittle hair []. Protein SICKLE is required for development and abiotic stress tolerance, and is involved in microRNA biogenesis []and mRNA splicing []. SICKLE, also known as ROTUNDA 3, may contribute to plant development by phosphatase 2A-mediated regulation of auxin transporter recycling []. |
