| Primary Identifier | IPR004305 | Type | Domain |
| Short Name | Thiaminase-2/PQQC |
| description | Proteins containing this domain are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. InBacillus subtilis, TenA is one of a number of proteins that enhance the expression of extracellular enzymes, such asalkaline protease, neutral protease and levansucrase []and has been identified as a Thiaminase 2 []. The THI-4 protein, which is involved in thiamine biosynthesis, also contains this domain. The C-terminal part of these proteins consistently show significant sequence similarity to TenA proteins. This similarity was first noted with the Neurospora crassa THI-4 []. This domain is also found in bacterial coenzyme PQQ synthesis protein C or PQQC. Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria []. PQQC has been found to be required in the synthesis of PQQ, but its function is unclear. |
