| Primary Identifier | IPR028367 | Type | Family |
| Short Name | CyclinC/Ssn8 |
| description | This entry represents cyclin C family, which includes cyclins C and yeast RNA polymerase II holoenzyme cyclin-like subunit (also known as Ssn8/Srb11).Cyclin C can regulate both cell cycle progression and gene transcription: cyclin C forms complexes with Cdk8 and induces the transcription of Cdk1. TheCdk8-cyclin C complex is a component of the RNA polymerase II holoenzyme, where it functions as a kinase that phosphorylates the C-terminal domain, and can alsorepress transcription by phosphorylating the Cdk7-cyclin H subunits of the general transcription initiator factor TFIIH []. The Cdk7-cyclin H complex can activate many other cyclin-Cdk complexes directly involved in cell cycle progression, such as Cdk2, Cdk4, and Cdc2 (Cdk1) [].Ssn8/Srb11 is a component of the SRB8-11 complex (consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11), which is a regulatory module of the mediator complex that is involved in regulation of basal and activated RNA polymerase II-dependent transcription [, ]. |
