| Primary Identifier | IPR015942 | Type | Family |
| Short Name | Asp/Glu/hydantoin_racemase |
| description | This entry represents a group of related proteins that includes aspartate racemase, glutamate racemase, hydantoin racemase and arylmalonate decarboxylase. Two conserved cysteines are present in the sequence of these enzymes. They play a role in catalytic activity by acting as bases in proton abstraction from the substrate [, , ].Aspartate racemase () and glutamate racemase () are two evolutionary related bacterial enzymes that do not seem to require a cofactor for their activity []. Glutamate racemase, which interconverts L-glutamate into D-glutamate, is required for the biosynthesis of peptidoglycan and some peptide-based antibiotics such as gramicidin S. The E.coli L-aspartate/glutamate specific racemase Ygea, which was previously an hypothetical protein, has been shown to have racemase activity for both L-glutamate and L-aspartate with higher preference for L-glutamate [].Hydantoin racemases catalyse the racemization of various 5-substituted hydantoins. The structure of the allantoin racemase from Klebsiella pneumoniae has been solved []. |
