| Primary Identifier | IPR041324 | Type | Domain |
| Short Name | AgI/II_N |
| description | This entry describes an N-terminal domain found in Antigen I/II (also known antigen B, PAc or adhesin P1).The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. The N terminus forms a stabilizing scaffold by wrapping behind the base of P1's elongated stalk and physically 'locking' it into place. It is suggested that the N-terminal has a pronounced impact on P1 immunogenicity, antigenicity, folding, stability, and adherent function [].This domain can also found in aggregation substance (Asa1) from Enterococcus faecalis. It is a structural homologue of Streptococcus mutans Antigen I/II. It acts as an adhesin mediating cell-cell contact between different E. faecalis strains and also binding of E. faecalis to eukaryotic cells [, ]. |
