| Primary Identifier | IPR041163 | Type | Domain |
| Short Name | Ret_CLD1 |
| description | Ret is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. It contains four consecutive cadherin-like domains (CLD). This entry represents the first CLD at the N-terminal. Several regions within RET-CLD1 have been shown to be important for ligand-coreceptor binding. CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is essential for CLD2 folding. CLD1 contains 2 sites for GDNF receptor alpha 1 binding []. |
