| Primary Identifier | IPR006853 | Type | Family |
| Short Name | Poxin_vir |
| description | This entry represents Poxin (poxvirus immune nucleases) from Baculovirus and Vaccinia virus. Poxin is a nuclease that cleaves host 2',3'-cGAMP []. In human hosts, enzyme cGAS recognizes cytosolic DNA and synthesizes 2'3' cGAMP to activate STING-dependent interferon and NF-kappaB immune responses. Poxin is the viral factor responsible for 2'3' cGAMP degradation []. Interestingly, in some poxviruses the poxin is expressed as a poxin-schlafen fusion protein. |
